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Volume 2023,
Issue 1,
December 6, 2023
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特别的书给特别的你-千龙网·中国首都网:2021-1-13 · 德国政论家、历史作家哈夫纳的回忆录《一个德国人的故事》,回顾了自己在两次世界大战之间度过的青年时伋,挖掘法西斯主义在德国滋生的原因。喜欢电影的文艺青年今年还将看到大量有关电影和文艺片导演的书籍,比如《朴赞郁的蒙太奇》(磨铁即将出版)。

This activity is supported by educational grants from Amgen, AstraZeneca, Celgene Corporation, Incyte Corporation, Jazz Pharmaceuticals, Inc., Novartis Pharmaceuticals, and Servier Pharmaceuticals, LLC.

Featured Content

Navigating the nexus of MRD and novel agents in ALL

The landscape of acute lymphoblastic leukemia (ALL) has evolved significantly over the last few years. Identification of specific recurrent genetic alterations and of minimal residual disease (MRD) guides prognostic classification and management. Novel agents (eg, blinatumomab) have demonstrated encouraging results in relapsed/refractory (R/R) and MRD+ patients and are currently incorporated into upfront treatment in specific settings. Other new strategies include the incorporation of tyrosine kinase inhibitor-based therapy for patients with Philadelphia chromosome–like ALL and the use of DOT inhibitors and bcl-2/bcl-xl inhibitors in R/R disease. These innovations promise to improve management and outcome in this disease.

How I treat a refractory myeloma patient who is not eligible for a clinical trial

Myeloma patients not eligible for clinical trials have many treatment options. Choosing the next best therapy starts with careful assessment of the biology and dynamics of the disease at relapse, as well as the condition and situation of the patient. Fit patients should be considered for triplet regimens, whereas intermediate and frail patients warrant dose-reduced triplets or doublets. An indolent serologic relapse may be treated with dose intensification, especially in a maintenance situation, whereas a rapid relapse requires a more aggressive approach with drug class change or a second-generation immunomodulatory drug (IMID) or proteasome inhibitor (PI). Monoclonal antibodies, in combination with PIs and IMIDs, have proven highly efficacious in early and late relapse. Key elements of supportive care include infection prevention, bone health, thromboprophylaxis, and management of active symptoms, such as pain and distress.

Idiopathic aplastic anemia vs hypocellular myelodysplastic syndrome

Proper diagnostic distinction of bone marrow failure syndromes can often be challenging. In particular, for older patients with idiopathic aplastic anemia (AA), differential diagnosis includes myelodysplastic syndrome (MDS), which can atypically present in a hypocellular form. In addition to blasts and overt dysplasia, the presence of chromosomal abnormalities and a spectrum of somatic mutations may be revealing. Both clonal cytogenetic aberrations and somatic mutations most typically correspond to a clonal myelodysplasia, but clonal somatic mutations have also recently been found in AA. True driver myeloid mutations are uncommon in AA. Marrow hypocellularity in AA and occasionally in MDS patients points toward a similar immune mechanism responsible for deficient blood cell production and indicates that cytopenias in early hypocellular MDS might be treated with immunosuppressive modalities. Primary hypocellular MDS has to be distinguished from post-AA secondary MDS, most commonly associated with del7/7q. Post-AA MDS evolves at the rate of about 10% in 10 years, but recent observations suggest that widespread use of eltrombopag may influence the risk of progression to MDS. This complication likely represents a clonal escape, with founder hits occurring early on in the course of AA. A similar mechanism operates in the evolution of paroxysmal nocturnal hemoglobinuria (PNH) in AA patients, but PNH clones are rarely encountered in primary MDS.

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齐鲁晚报:2021-7-24 · 《齐鲁晚报》(电子版)的一切内容(包括但不限于文字、图片、PDF、图表、标志、标识、商标、版面设计、专栏目录与名称、内容分类标准伍及为读者提供的任何信息)仅供齐鲁晚报的报、网、端、微等载体读者阅读、学习研究使用,未经本单位书面授权,任何单位及个人不得将《齐鲁晚报》(电子 ...

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